Assessment of blood lipid levels in persons engaged in harmful by intensity mental work, under including in diet plant-based products

Introduction. Consumption of nutrients promoting the normalization of lipid metabolism allows correcting dyslipidemia, which is important for people engaged in mental work.

Purpose. An assessment of blood lipids in persons engaged in mental work that is harmful due to the intensity of the work process, when including in their diet a product made from plant materials.

Materials and methods. The study involved men aged 35.7 ± 4.9 years who had been engaged in mental labor for 10.6 ± 0.9 years. Working conditions were assessed based on indicators of work intensity. Subjects in Group 1 (n = 30) consumed a multicomponent herbal product produced using cryotechnology for 21 days; Group 2 (n = 30) served as a comparison group. Daily micronutrient intake was calculated. Blood lipid and cortisol levels were determined at baseline, on days 22, and 32.

Results. In terms of the intensity of the work process, the work is harmful (degree 3.3). When taking the product, a decrease in total cholesterol was determined (to 4.78 ± 0.63 from 5.0 ± 0.75 mmol/l (p = 0.003), an increase of 13.4% in the proportion of people with normal and a decrease of 10.0% with high cholesterol, an increase of 4.1% in the proportion of people with high high-density lipoproteins, a decrease of 11.9% in the proportion with high low-density lipoproteins; lipid atherogenicity decreased by 15.5%. In the comparison group, high high-density lipoproteins tended to decrease, low density to increase. Blood atherogenicity in the main group initially exceeded the norm in 22.2%, at the end of the observation in 6.7%, in the comparison group, respectively, in 36.7% and 53.3%. The effect on anabolic processes and stress levels was evidenced by the hormone cortisol: a decrease in 66.7% in the main group group and growth in 43.3% in the comparison group.

Research limitations. Men under 40 years of age, occupationally engaged in mental work, assessed according to the degree of harmfulness and danger as harmful level 3.3.

Conclusions. Optimization of nutrition with a natural multi-component product from plant raw materials is a method for preventing dyslipidemia and stress during long-term intense harmful mental work.

Compliance with ethical standards. The study was approved by the Ethics Committee of the Primary Medical University (Protocol No. 4, dated March 14, 2022).

Contribution of the authors:
Rakhmanov R.S. — concept and design of the study, writing the text;
Bogomolova E.S. — writing and editing the text;
Narutdinov D.A. — collection of primary material;
Razgulin S.A. — collection of literary data and compilation of the list of references;
Potekhina N.N. — participation in the preparation of the text and statistical processing of the material;
Khairov R.Sh. — statistical processing of the material.
All co-authors — approval of the final version of the article, responsibility for the integrity of all parts of the article.

Funding. The study had no sponsorship.

Conflict of interest. The authors declare no obvious or potential conflicts of interest in connection with the publication of this article.

Received: February 10, 2025 / Revised: May 26, 2025 / Accepted: February 19, 2026 / Published: April 30, 2026

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