THE CHARACTERISTICS OF FUNCTIONAL CONDITION OF CENTRAL NERVOUS SYSTEM IN INDIVIDUALS WITH CHRONIC INSOMNIA AND PROGNOSIS OF DEVELOPMENT OF SLEEP DISORDERS

The higher prevalence and variety of clinical manifestation of disorders of falling asleep and sleep maintenance (insomnia) in persons of able-bodied age condition necessity of development of personified prevention programs subject to main pathophysiologic mechanisms conditioning risks of development of sleep disorders and related to them somatic diseases. Purpose of study. To analyze functional state of brain and cerebral blood flow in brain workers with higher level of professional stress and sleep disorders and to determine risk factors of development of established disorders for scientific substantiation of preventive activities. Material and methods. The examination was applied to two groups of brain workers with higher level of work intensity (class 3.3) and professional stress. The main group included 77 individuals stated availability of insomnia (index of insomnia severity 20.4±3.1 points). The control group included 88 individuals without significant sleep disorders. The clinical instrumental examination was implemented including questionnaire survey, night polysome graphic analysis, electroencephalography (EEG) and rheography analysis. Results. The high level of professional stress in workers with sleep disorders was statistically related to decreasing of efficiency of total time of sleep, decreasing of slow-wave sleep шт its structure, increased sleep fragmentation due to increasing of reactions of EEG-activation (r=0.35). The study of cerebral blood flow established that in 50% of individuals with sleep disorders and 32% of individuals without sleep disorders the instability of vascular tone was registered. According data of prospective observation, the signs of sleep disorders continued in 92% of patients with non-specific alterations of EEG with predominance of low-amplitude high-frequency activity and in 65% of patients with absence of similar alterations. The detected alterations can be considered as markers of condition of increased reactivity of central and vegetative nervous system being predisposing factor of changing from acute or transitory insomnia to chronic form.

chronic insomnia, professional stress, functional condition, central nervous system, polysome graphic analysis, electroencephalography analysis, rheography analysis, cerebral vessels, prevention of sleep disorders

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