rfhealthЗдравоохранение Российской ФедерацииHealth care of the Russian Federation0044-197X2412-0723Federal Scientific Center of Hygiene named after F.F. Erisman10.47470/0044-197X-2021-65-5-447-453rfhealth-602Research ArticleПРОФИЛАКТИКА НЕИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙPREVENTION OF NONINFECTIOUS DISEASESКоррекция обеспеченности организма селеном как инструмент профилактической медициныCorrection of Selenium status as a tool for preventive medicinehttps://orcid.org/0000-0003-4785-2668МазилинаА. Н.MazilinaAksana N.noemail@neicon.ruhttps://orcid.org/0000-0001-7838-1366СкальныйА. В.SkalnyAnatoly V.noemail@neicon.ruhttps://orcid.org/0000-0002-9959-6507РакитскийВ. Н.RakitskiiValerii N.noemail@neicon.ruhttps://orcid.org/0000-0002-0658-9130РусановА. С.RusanovAleksander S.noemail@neicon.ruhttps://orcid.org/0000-0002-5498-1807ЧерноваЛ. Н.ChernovaLyubov N.noemail@neicon.ruhttps://orcid.org/0000-0003-0348-6192ТиньковАлексей АлексеевичTinkovAlexey A.

Канд. мед. наук, ст. науч. сотр. Центра цифрового биодизайна и персонализированного здравоохранения, ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова МЗ РФ (Сеченовский Университет)», 119991, Москва.

e-mail: tinkov.a.a@gmail.com

MD, PhD, Senior Researcher at the Center for Digital Biodesign and Personalized Health Care of Sechenov University, Moscow, 119991, Russian Federation.

e-mail: tinkov.a.a@gmail.com

tinkov.a.a@gmail.comФГБУ «Федеральный научно-клинический центр физико-химической медицины» Федерального медико-биологического агентства России; ФГАОУ ВО «Российский университет дружбы народов»РоссияFederal Research and Clinical Center of Physical-Chemical Medicine of the Federal Biomedical Agency of Russia; Peoples’ Friendship University of Russia (RUDN University)Russian FederationФГАОУ ВО «Российский университет дружбы народов»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)»РоссияPeoples’ Friendship University of Russia (RUDN University); I.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationИнститут гигиены, токсикологии пестицидов и химической безопасности ФБУН «Федеральный научный центр гигиены имени Ф.Ф. Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человекаРоссияF.F. Erisman Federal Research Center of Hygiene, Institute of Hygiene, Pesticides Toxicology and Chemical SafetyRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)»РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationФГАОУ ВО «Российский университет дружбы народов»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)»; ФГБОУ ВО «Ярославский государственный университет имени П.Г. Демидова»РоссияPeoples’ Friendship University of Russia (RUDN University); I.M. Sechenov First Moscow State Medical University (Sechenov University); P.G. Demidov Yaroslavl State UniversityRussian Federation202111112021655447453Copyright © Мазилина А.Н., Скальный А.В., Ракитский В.Н., Русанов А.С., Чернова Л.Н., Тиньков А.А., 20212021Мазилина А.Н., Скальный А.В., Ракитский В.Н., Русанов А.С., Чернова Л.Н., Тиньков А.А.Mazilina A.N., Skalny A.V., Rakitskii V.N., Rusanov A.S., Chernova L.N., Tinkov A.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rfhealth.ru/jour/article/view/602Введение

Введение. Вследствие большого количества физиологических эффектов селена его дефицит связан с широким спектром нарушений. 

Цель работы — анализ эпидемиологических данных относительно взаимосвязи уровня селена со здоровьем населения и возможности коррекции селенсодержащими препаратами. 

Материал и методы

Материал и методы. Поиск материала осуществлялся по ключевым словам в базах PubМed, The Cochrane Library, Google Scholar. 

Результаты

Результаты. Мета-анализы, размещённые в базе Cochrane, продемонстрировали взаимосвязь между уровнем селена и рядом патологий. Так, лица, наиболее обеспеченные селеном, характеризуются на 24–31% меньшим риском развития рака и на 36% меньшей смертностью от онкологических заболеваний. Стоит также отметить, что употребление селена во время беременности женщинами с ВИЧ, не получавшими антиретровирусную терапию, снижало риск низкой массы при рождении и развития диареи у беременных. Дополнительное введение селена недоношенным новорождённым или новорождённым с критически низкой массой тела сопровождалось снижением риска сепсиса. Эффективность нормализации обеспеченности организма селеном в отношении риска ишемической болезни сердца и летального исхода при сепсисе также была продемонстрирована в крупных эпидемиологических исследованиях, не входящих в базу Cochrane. Мониторинг уровня селена в организме важен как с точки зрения оценки эффективности проводимых мероприятий, так и с целью выявления возможных негативных проявлений, связанных с токсичным эффектом селена в условиях его избытка. При этом отмечается, что обеспеченность селеном является определяющим фактором профилактики сердечно-сосудистых и онкологических заболеваний. 

Заключение

Заключение. Учитывая широкую распространённость дефицита селена у населения России (24–45% в зависимости от региона проживания), оценка статуса селена и своевременная коррекция выявленного дисбаланса может рассматриваться в качестве приоритетного направления сохранения здоровья населения.

Introduction

Introduction. Due to the many physiological functions of Selenium (Se), its deficiency is associated with a broad spectrum of adverse health effects. 

This review aims to analyze epidemiological data on the relation of selenium status to public health and the possibility of selenium-containing drugs usage. 

Material and methods

Material and methods. Based on the literature search in Pubmed, The Cochrane Library, and Google Scholar, epidemiological data on the association between Se status and population health and effects of Se supplementation were analyzed. 

Results

Results. Meta-analyses indexed in the Cochrane Library demonstrated a significant association between Se status and many pathologies. Specifically, it has been shown that subjects with physiologically high Se body burden are characterized by a 24–31% lower risk of cancer and 36% lower risk of cancer-related mortality. It is also notable that Se supplementation in human immunodeficiency virus-infected women reduced the risk of maternal diarrhoea and low birth mass in offspring. Moreover, Se supplementation in premature newborns and critically low mass newborns significantly decreased the risk of sepsis. Many extensive epidemiological studies also demonstrated the efficiency of improvement in the Se status concerning coronary heart disease and sepsis mortality risk. At the same time, constant monitoring of Se body burden is essential for assessing Se supplementation efficiency and prevention of adverse health effects of Se overload. It is also noted that Se status is considered as the determinant of the efficiency of prevention of cardiovascular diseases and cancer under Se supplementation. 

Conclusion

Conclusion. Given the high incidence of Se deficiency in Russia (24–45% depending on the region), assessment and improvement of Se status may be considered a valuable tool for population health management.

селенпрофилактикадолголетиедемографияseleniumpreventionlongevitydemographicsReferencesJunior E.L., Leite H.P., Konstantyner T. Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes. Transl. Res. 2019; 208: 85-104. https://doi.org/10.1016/j.trsl.2019.01.004Junior E.L., Leite H.P., Konstantyner T. Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes. Transl. Res. 2019; 208: 85-104. https://doi.org/10.1016/j.trsl.2019.01.004Fordyce F.M. Selenium deficiency and toxicity in the environment. In: Essentials of Medical Geology. Dordrecht: Springer; 2013: 375-416.Fordyce F.M. Selenium deficiency and toxicity in the environment. In: Essentials of Medical Geology. Dordrecht: Springer; 2013: 375-416.Jones G.D., Droz B., Greve P., Gottschalk P., Poffet D., McGrath S.P., et al. Selenium deficiency risk predicted to increase under future climate change. Proc. Natl Acad. Sci. 2017; 114(11): 2848-53. https://doi.org/10.1073/pnas.1611576114Jones G.D., Droz B., Greve P., Gottschalk P., Poffet D., McGrath S.P., et al. Selenium deficiency risk predicted to increase under future climate change. Proc. Natl Acad. Sci. 2017; 114(11): 2848-53. https://doi.org/10.1073/pnas.1611576114Rayman M. Selenium intake and status in health & disease. Free Radic. Biol. Med. 2017; 112(S1): 5. https://doi.org/10.1016/j.freeradbiomed.2017.10.353Rayman M. Selenium intake and status in health & disease. Free Radic. Biol. Med. 2017; 112(S1): 5. https://doi.org/10.1016/j.freeradbiomed.2017.10.353Kipp A.P., Strohm D., Brigelius-Flohé R., Schomburg L., Bechthold A., Leschik-Bonnet E., et al. Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 2015; 32: 195-9. https://doi.org/10.1016/j.jtemb.2015.07.005Kipp A.P., Strohm D., Brigelius-Flohé R., Schomburg L., Bechthold A., Leschik-Bonnet E., et al. Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 2015; 32: 195-9. https://doi.org/10.1016/j.jtemb.2015.07.005Vinceti M., Filippini T., Wise L.A. Environmental selenium and human health: an update. Curr. Environ. Health Rep. 2018; 5(4): 464-85. https://doi.org/10.1007/s40572-018-0213-0Vinceti M., Filippini T., Wise L.A. Environmental selenium and human health: an update. Curr. Environ. Health Rep. 2018; 5(4): 464-85. https://doi.org/10.1007/s40572-018-0213-0Vinceti M., Vicentini M., Wise L.A., Sacchettini C., Malagoli C., Ballotari P., et al. Cancer incidence following long-term consumption of drinking water with high inorganic selenium content. Sci. Total Environ. 2018; 635: 390-6. https://doi.org/10.1016/j.scitotenv.2018.04.097Vinceti M., Vicentini M., Wise L.A., Sacchettini C., Malagoli C., Ballotari P., et al. Cancer incidence following long-term consumption of drinking water with high inorganic selenium content. Sci. Total Environ. 2018; 635: 390-6. https://doi.org/10.1016/j.scitotenv.2018.04.097Benstoem C., Goetzenich A., Kraemer S., Borosch S., Manzanares W., Hardy G., et al. Selenium and its supplementation in cardiovascular disease - what do we know? Nutrients. 2015; 7(5): 3094-118. https://doi.org/10.3390/nu7053094Benstoem C., Goetzenich A., Kraemer S., Borosch S., Manzanares W., Hardy G., et al. Selenium and its supplementation in cardiovascular disease - what do we know? Nutrients. 2015; 7(5): 3094-118. https://doi.org/10.3390/nu7053094Zhang X., Liu C., Guo J., Song Y. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur. J. Clin. Nutr. 2016; 70(2): 162-9. https://doi.org/10.1038/ejcn.2015.78Zhang X., Liu C., Guo J., Song Y. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. Eur. J. Clin. Nutr. 2016; 70(2): 162-9. https://doi.org/10.1038/ejcn.2015.78Rayman M.P., Duntas L.H. Selenium deficiency and thyroid disease. In: The Thyroid and Its Diseases. Cham: Springer; 2019: 109-26.Rayman M.P., Duntas L.H. Selenium deficiency and thyroid disease. In: The Thyroid and Its Diseases. Cham: Springer; 2019: 109-26.Скальный А.В., Киселев М.Ф., ред. Элементный статус населения России. СПб.: Медкнига ЭЛБИ-СПб; 2013Skalnyy A.V., Kiselev M.F., eds. The Elemental Status of the Population of Russia [Elementnyy status naseleniya Rossii]. St. Petersburg: Medkniga ELBI-SPb; 2013. (in Russian)Klimenko L.L., Skalny A.V., Turna A.A., Tinkov A.A., Budanova M.N., Baskakov I.S., et al. Serum trace element profiles, prolactin, and cortisol in transient ischemic attack patients. Biol. Trace Elem. Res. 2016; 172(1): 93-100. https://doi.org/10.1007/s12011-015-0586-yKlimenko L.L., Skalny A.V., Turna A.A., Tinkov A.A., Budanova M.N., Baskakov I.S., et al. Serum trace element profiles, prolactin, and cortisol in transient ischemic attack patients. Biol. Trace Elem. Res. 2016; 172(1): 93-100. https://doi.org/10.1007/s12011-015-0586-ySkalny A.V., Klimenko L.L., Turna A.A., Budanova M.N., Baskakov I.S., Savostina M.S., et al. Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke. Metab. Brain Dis. 2017; 32(3): 779-88. https://doi.org/10.1007/s11011-017-9967-6Skalny A.V., Klimenko L.L., Turna A.A., Budanova M.N., Baskakov I.S., Savostina M.S., et al. Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke. Metab. Brain Dis. 2017; 32(3): 779-88. https://doi.org/10.1007/s11011-017-9967-6Skalny A.V., Skalnaya M.G., Klimenko L.L., Mazilina A.N., Tinkov A.A. Selenium in Ischemic Stroke. In: Selenium. Cham: Springer; 2018: 211-30.Skalny A.V., Skalnaya M.G., Klimenko L.L., Mazilina A.N., Tinkov A.A. Selenium in Ischemic Stroke. In: Selenium. Cham: Springer; 2018: 211-30.Hu X.F., Eccles K.M., Chan H.M. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ. Int. 2017; 102: 200-6. https://doi.org/10.1016/j.envint.2017.03.002Hu X.F., Eccles K.M., Chan H.M. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environ. Int. 2017; 102: 200-6. https://doi.org/10.1016/j.envint.2017.03.002Virtamo J., Valkeila E., Alfthan G., Punsar S., Huttunen J.K., Karvonen M.J. Serum selenium and the risk of coronary heart disease and stroke. Am. J. Epidemiol. 1985; 122(2): 276-82. https://doi.org/10.1093/oxfordjournals.aje.a114099Virtamo J., Valkeila E., Alfthan G., Punsar S., Huttunen J.K., Karvonen M.J. Serum selenium and the risk of coronary heart disease and stroke. Am. J. Epidemiol. 1985; 122(2): 276-82. https://doi.org/10.1093/oxfordjournals.aje.a114099Bleys J., Navas-Acien A., Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch. Intern. Med. 2008; 168(4): 404-10. https://doi.org/10.1001/archinternmed.2007.74Bleys J., Navas-Acien A., Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch. Intern. Med. 2008; 168(4): 404-10. https://doi.org/10.1001/archinternmed.2007.74Merrill P.D., Ampah S.B., He K., Rembert N.J., Brockman J., Kleindorfer D., et al. Association between trace elements in the environment and stroke risk: The reasons for geographic and racial differences in stroke (REGARDS) study. J. Trace Elem. Med. Biol. 2017; 42: 45-9. https://doi.org/10.1016/j.jtemb.2017.04.003Merrill P.D., Ampah S.B., He K., Rembert N.J., Brockman J., Kleindorfer D., et al. Association between trace elements in the environment and stroke risk: The reasons for geographic and racial differences in stroke (REGARDS) study. J. Trace Elem. Med. Biol. 2017; 42: 45-9. https://doi.org/10.1016/j.jtemb.2017.04.003FAO, WHO. Human vitamin and mineral requirements. Report of a Joint FAO/WHO Expert Consultation. Bangkok, Thailand, Rome: Food and Nutrition Division, FAO; 2001: 235-47.FAO, WHO. Human vitamin and mineral requirements. Report of a Joint FAO/WHO Expert Consultation. Bangkok, Thailand, Rome: Food and Nutrition Division, FAO; 2001: 235-47.Aro A., Alfthan G., Varo P. Effects of supplementation of fertilizers on human selenium status in Finland. Analyst. 1995; 120(3): 841-3. https://doi.org/10.1039/an9952000841Aro A., Alfthan G., Varo P. Effects of supplementation of fertilizers on human selenium status in Finland. Analyst. 1995; 120(3): 841-3. https://doi.org/10.1039/an9952000841Alfthan G., Eurola M., Ekholm P., Venäläinen E.R., Root T., Korkalainen K., et al. Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population. J. Trace Elem. Med. Biol. 2015; 31: 142-7. https://doi.org/10.1016/j.jtemb.2014.04.009Alfthan G., Eurola M., Ekholm P., Venäläinen E.R., Root T., Korkalainen K., et al. Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population. J. Trace Elem. Med. Biol. 2015; 31: 142-7. https://doi.org/10.1016/j.jtemb.2014.04.009Lyons G.H., Judson G.J., Ortiz-Monasterio I., Genc Y., Stangoulis J.C., Graham R.D. Selenium in Australia: selenium status and biofortification of wheat for better health. J. Trace Elem. Med. Biol. 2005; 19(1): 75-82. https://doi.org/10.1016/j.jtemb.2005.04.005Lyons G.H., Judson G.J., Ortiz-Monasterio I., Genc Y., Stangoulis J.C., Graham R.D. Selenium in Australia: selenium status and biofortification of wheat for better health. J. Trace Elem. Med. Biol. 2005; 19(1): 75-82. https://doi.org/10.1016/j.jtemb.2005.04.005Cai X., Wang C., Yu W. Selenium exposure and cancer risk: An updated meta-analysis and meta-regression. Sci. Rep. 2016; 6: 19213. https://doi.org/10.1038/srep19213Cai X., Wang C., Yu W. Selenium exposure and cancer risk: An updated meta-analysis and meta-regression. Sci. Rep. 2016; 6: 19213. https://doi.org/10.1038/srep19213Vinceti M., Dennert G., Crespi C.M., Dennert G., Zwahlen M., Brinkman M., et al. Selenium for preventing cancer. Cochrane Database Syst Rev. 2014; 2014(3): CD005195. https://doi.org/10.1002/14651858.CD005195.pub3Vinceti M., Dennert G., Crespi C.M., Dennert G., Zwahlen M., Brinkman M., et al. Selenium for preventing cancer. Cochrane Database Syst Rev. 2014; 2014(3): CD005195. https://doi.org/10.1002/14651858.CD005195.pub3Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004; 364(9441): 1219-28. https://doi.org/10.1016/S0140-6736(04)17138-9Bjelakovic G., Nikolova D., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004; 364(9441): 1219-28. https://doi.org/10.1016/S0140-6736(04)17138-9Lee E.H., Myung S.K., Jeon Y.J., Kim Y., Chang Y.J., Ju W., et al. Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutr. Cancer. 2011; 63(8): 1185-95. https://doi.org/10.1080/01635581.2011.607544Lee E.H., Myung S.K., Jeon Y.J., Kim Y., Chang Y.J., Ju W., et al. Effects of selenium supplements on cancer prevention: meta-analysis of randomized controlled trials. Nutr. Cancer. 2011; 63(8): 1185-95. https://doi.org/10.1080/01635581.2011.607544Fritz H., Kennedy D., Fergusson D., Fernandes R., Cooley K., Seely A., et al. Selenium and lung cancer: a systematic review and meta-analysis. PLoS One. 2011; 6(11): e26259. https://doi.org/10.1371/journal.pone.0026259Fritz H., Kennedy D., Fergusson D., Fernandes R., Cooley K., Seely A., et al. Selenium and lung cancer: a systematic review and meta-analysis. PLoS One. 2011; 6(11): e26259. https://doi.org/10.1371/journal.pone.0026259Siegfried N., Irlam J.H., Visser M.E., Rollins N.N. Micronutrient supplementation in pregnant women with HIV infection. Cochrane Database Syst. Rev. 2012; (3): CD009755. https://doi.org/10.1002/14651858.CD009755Siegfried N., Irlam J.H., Visser M.E., Rollins N.N. Micronutrient supplementation in pregnant women with HIV infection. Cochrane Database Syst. Rev. 2012; (3): CD009755. https://doi.org/10.1002/14651858.CD009755Darlow B.A., Austin N.C. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst. Rev. 2003; (4): CD003312. https://doi.org/10.1002/14651858.CD003312Darlow B.A., Austin N.C. Selenium supplementation to prevent short-term morbidity in preterm neonates. Cochrane Database Syst. Rev. 2003; (4): CD003312. https://doi.org/10.1002/14651858.CD003312Flores-Mateo G., Navas-Acien A., Pastor-Barriuso R., Guallar E. Selenium and coronary heart disease: a meta-analysis. Am. J. Clin. Nutr. 2006; 84(4): 762-73. https://doi.org/10.1093/ajcn/84.4.762Flores-Mateo G., Navas-Acien A., Pastor-Barriuso R., Guallar E. Selenium and coronary heart disease: a meta-analysis. Am. J. Clin. Nutr. 2006; 84(4): 762-73. https://doi.org/10.1093/ajcn/84.4.762Huang T.S., Shyu Y.C., Chen H.Y., Lin L.M., Lo C.Y., Yuan S.S., et al. Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS One. 2013; 8(1): e54431. https://doi.org/10.1371/journal.pone.0054431Huang T.S., Shyu Y.C., Chen H.Y., Lin L.M., Lo C.Y., Yuan S.S., et al. Effect of parenteral selenium supplementation in critically ill patients: a systematic review and meta-analysis. PLoS One. 2013; 8(1): e54431. https://doi.org/10.1371/journal.pone.0054431Alhazzani W., Jacobi J., Sindi A., Hartog C., Reinhart K., Kokkoris S., et al. The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit. Care Med. 2013; 41(6): 1555-64. https://doi.org/10.1097/CCM.0b013e31828a24c6Alhazzani W., Jacobi J., Sindi A., Hartog C., Reinhart K., Kokkoris S., et al. The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit. Care Med. 2013; 41(6): 1555-64. https://doi.org/10.1097/CCM.0b013e31828a24c6Landucci F., Mancinelli P., De Gaudio A.R., Virgili G. Selenium supplementation in critically ill patients: a systematic review and meta-analysis. J. Crit. Care. 2014; 29(1): 150-6. https://doi.org/10.1016/j.jcrc.2013.08.017Landucci F., Mancinelli P., De Gaudio A.R., Virgili G. Selenium supplementation in critically ill patients: a systematic review and meta-analysis. J. Crit. Care. 2014; 29(1): 150-6. https://doi.org/10.1016/j.jcrc.2013.08.017Zou K., Liu G., Wu T., Du L. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthritis Cartilage. 2009; 17(2): 144-51. https://doi.org/10.1016/j.joca.2008.06.011Zou K., Liu G., Wu T., Du L. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthritis Cartilage. 2009; 17(2): 144-51. https://doi.org/10.1016/j.joca.2008.06.011Toulis K.A., Anastasilakis A.D., Tzellos T.G., Goulis D.G., Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010; 20(10): 1163-73. https://doi.org/10.1089/thy.2009.0351Toulis K.A., Anastasilakis A.D., Tzellos T.G., Goulis D.G., Kouvelas D. Selenium supplementation in the treatment of Hashimoto’s thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010; 20(10): 1163-73. https://doi.org/10.1089/thy.2009.0351Lenz M., Lens P.N. The essential toxin: the changing perception of selenium in environmental sciences. Sci. Total Environ. 2009; 407(12): 3620-33. https://doi.org/10.1016/j.scitotenv.2008.07.056Lenz M., Lens P.N. The essential toxin: the changing perception of selenium in environmental sciences. Sci. Total Environ. 2009; 407(12): 3620-33. https://doi.org/10.1016/j.scitotenv.2008.07.056Stranges S., Sieri S., Vinceti M., Grioni S., Guallar E., Laclaustra M., et al. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. 2010; 10: 564. https://doi.org/10.1186/1471-2458-10-564Stranges S., Sieri S., Vinceti M., Grioni S., Guallar E., Laclaustra M., et al. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. 2010; 10: 564. https://doi.org/10.1186/1471-2458-10-564Vinceti M., Bonvicini F., Rothman K.J. The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study. Environ. Health. 2010; 9: 77. https://doi.org/10.1186/1476-069X-9-77Vinceti M., Bonvicini F., Rothman K.J. The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study. Environ. Health. 2010; 9: 77. https://doi.org/10.1186/1476-069X-9-77

The authors declare that there are no conflicts of interest present.