rfhealthЗдравоохранение Российской ФедерацииHealth care of the Russian Federation0044-197X2412-0723Federal Scientific Center of Hygiene named after F.F. Erisman10.18821/0044-197Х-2017-61-3-128-132rfhealth-32Research ArticleСОЦИАЛЬНАЯ ГИГИЕНА И ОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯSOCIAL HYGIENE AND HEALTH CARE ORGANIZATIONОЦЕНКА РИСКА РАЗВИТИЯ И ТЕЧЕНИЯ БРОНХИАЛЬНОЙ АСТМЫ НА ОСНОВЕ ПОЛИМОРФИЗМА ГЕНА TNFATHE EVALUATION OF RISK OF DEVELOPMENT AND COURSE OF BRONCHIAL ASTHMA ON THE BASIS OF POLYMORPHISM OF GENE TNFAМухаммадиеваГ. Ф.MukhammadievaG. F.ufniimt@mail.rКутлинаТ. Г.KutlinaT. G.noemail@neicon.ruКаримовД. О.KarimovD. O.noemail@neicon.ruВаловаЯ. В.ValovaYa. V.noemail@neicon.ruСеребряковП. В.SerebryakovP. V.noemail@neicon.ruМелентьевА. В.Melent’EvA. V.noemail@neicon.ruБакировА. Б.BakirovA. B.noemail@neicon.ruШагалинаА. У.ShagalinaA. U.noemail@neicon.ruИдиятуллинаЭ. Ф.IdiyatullinaE. F.noemail@neicon.ruФБУН «Уфимский НИИ медицины труда и экологии человека» РоспотребнадзораUfa Research Institute of Labor and Human EcologyФБУН «Уфимский НИИ медицины труда и экологии человека» Роспотребнадзора; ФГБОУ ВО «Башкирский государственный университет»Ufa Research Institute of Labor and Human Ecology; Bashkir State UniversityФБУН «Федеральный научный центр гигиены им. Ф.Ф. Эрисмана» РоспотребнадзораThe F.F. Erisman Federal Research Сenter of Hygiene201716062020613128132Copyright © Мухаммадиева Г.Ф., Кутлина Т.Г., Каримов Д.О., Валова Я.В., Серебряков П.В., Мелентьев А.В., Бакиров А.Б., Шагалина А.У., Идиятуллина Э.Ф., 20202020Мухаммадиева Г.Ф., Кутлина Т.Г., Каримов Д.О., Валова Я.В., Серебряков П.В., Мелентьев А.В., Бакиров А.Б., Шагалина А.У., Идиятуллина Э.Ф.Mukhammadieva G.F., Kutlina T.G., Karimov D.O., Valova Y.V., Serebryakov P.V., Melent’Ev A.V., Bakirov A.B., Shagalina A.U., Idiyatullina E.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rfhealth.ru/jour/article/view/32

Бронхиальная астма (БА) является одним из наиболее распространенных многофакторных заболеваний, развивающихся при взаимодействии средовых и генетических факторов. Целью настоящей работы явился анализ ассоциации полиморфизма гена TNFA с риском развития БА с учетом клинической формы заболевания. Методом полимеразной цепной реакции изучен полиморфный локус rs1800629 гена TNFA у больных БА (133) и контрольной группы (195). При анализе частоты полиморфизма гена TNFA показано достоверное увеличение частоты аллеля A в группе больных БА по сравнению с контрольной выборкой. Согласно коэффициенту отношения шансов, риск развития БА при наличии аллеля A полиморфного локуса rs1800629 гена TNFA увеличивается более чем в 2 раза (OR = 2,53; 95% CI 1,45-4,43). При этом различные формы БА имеют специфические особенности в распределении частот генотипов полиморфного локуса rs1800629 гена TNFA. Показано, что среди носителей генотипа GA полиморфного варианта rs1800629 гена TNFA чаще встречались больные со смешанной формой БА, чем среди носителей генотипа GG. Полученные результаты дают основание предположить, что полиморфный вариант rs1800629 гена TNFA оказывает определенное повреждающее действие при различных клинических формах БА.

The bronchial asthma is one of the most widespread multi-factorial diseases developing in interaction of environmental and genetic factors. The purpose of this study was to analyze association of polymorphism of gene TNFA with risk of development of bronchial asthma considering clinical form of disease. The polymerase chain reaction technique was applied to analyze polymorphic locus rs1800629 of gene TNFA in patients with bronchial asthma (n=133) and control group (n=195). The analysis of rate of polymorphism of gene TNFA established reliable increasing of rate of allele A in group of patients with bronchial asthma as compared with control sample. According the coefficient of chances ratio, the risk of development of bronchial asthma if there is allele A of polymorphic locus rs1800629 of gene TNFA increases more than twice (OR=2,53; 95% CI 1,45-4,43). At that, various firms of bronchial asthma have specific features in distribution of rates of genotypes of polymorphic locus rs1800629 of gene TNFA. It is demonstrated that among agents of genotypes GA of polymorphic modification of rs1800629 of gene TNFA patients with mixed form of bronchial asthma were found more frequently than among agents of genotypes GG. The obtained results provide ground to suppose that polymorphic modification of rs1800629 of gene TNFA shows certain damaging effect under various clinical forms of bronchial asthma.

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The authors declare that there are no conflicts of interest present.