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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rfhealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Российской Федерации</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of the Russian Federation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0044-197X</issn><issn pub-type="epub">2412-0723</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.46563/0044-197X-2020-64-5-264-270</article-id><article-id custom-type="elpub" pub-id-type="custom">rfhealth-220</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОБЛЕМЫ СОЦИАЛЬНО ЗНАЧИМЫХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROBLEMS OF SOCIALLY SIGNIFICANT DISEASES</subject></subj-group></article-categories><title-group><article-title>Совершенствование организации диспансерного наблюдения за детьми группы риска во фтизиатрии</article-title><trans-title-group xml:lang="en"><trans-title>Improvement of institutions for dispensary observation of children from the risk group in phthisiology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0384-1705</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарапова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharapova</surname><given-names>Olga V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5985-1780</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брынза</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Brynza</surname><given-names>Natalya S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6529-372X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кича</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kicha</surname><given-names>Dmitry I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3976-0934</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимова</surname><given-names>Людмила Ивановна</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimova</surname><given-names>Lyudmila I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д-р мед. наук, проф., зав. учебно-методическим кабинетом ГБУЗ «Городская клиническая больница имени В.В. Виноградова» ДЗМ, 117292, Москва.</p><p>e-mail: profgera@mail.ru</p></bio><bio xml:lang="en"><p>MD, Ph.D., DSci., head of the educational and methodological office of the V.V. Vinogradov Municipal clinical hospital, Moscow, 117292, Russia.</p><p>e-mail: profgera@mail.ru</p></bio><email xlink:type="simple">profgera@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9975-5635</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слащева</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Slashcheva</surname><given-names>Daria M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8415-9961</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирогова</surname><given-names>Н. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Pirogova</surname><given-names>Natalia D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1567-3710</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрушина</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrushina</surname><given-names>Antonina D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Городская клиническая больница имени В.В. Виноградова Департамента здравоохранения города Москвы»<country>Россия</country></aff><aff xml:lang="en">Vinogradov V.V. Municipal clinical hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Tyumen State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов» Министерства науки и высшего образования России<country>Россия</country></aff><aff xml:lang="en">Peoples’ Friendship University of Russia, RUDN University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ГБУЗ Тюменской области «Областной противотуберкулёзный диспансер»<country>Россия</country></aff><aff xml:lang="en">Regional Clinical TB Dispensary<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2020</year></pub-date><volume>64</volume><issue>5</issue><fpage>264</fpage><lpage>270</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарапова О.В., Брынза Н.С., Кича Д.И., Герасимова Л.И., Слащева Д.М., Пирогова Н.Д., Петрушина А.Д., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Шарапова О.В., Брынза Н.С., Кича Д.И., Герасимова Л.И., Слащева Д.М., Пирогова Н.Д., Петрушина А.Д.</copyright-holder><copyright-holder xml:lang="en">Sharapova O.V., Brynza N.S., Kicha D.I., Gerasimova L.I., Slashcheva D.M., Pirogova N.D., Petrushina A.D.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rfhealth.ru/jour/article/view/220">https://www.rfhealth.ru/jour/article/view/220</self-uri><abstract><sec><title>Введение</title><p>Введение. Туберкулёз в России представляет одну из первостепенных проблем эпидемиологии и здравоохранения.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: провести анализ эпидемической ситуации по туберкулёзу в группах повышенного риска детей и подростков Тюменской области.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проанализированы годовые отчетные формы № 33 «Сведения о больных туберкулёзом» за 2014-2018 гг. в Тюменской области.</p></sec><sec><title>Результаты</title><p>Результаты. По данным собственного исследования, материалов исследований в регионе, рекомендаций ВОЗ по ликвидации туберкулёза к 2035 г., обоснована необходимость разработки новых подходов и практических рекомендаций по клиническому диспансерному наблюдению за детьми с измененной туберкулиновой чувствительностью.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Эпидемическая ситуация среди детей с измененной туберкулиновой чувствительностью к 2018 г. в районах Тюменской области характеризуется своей неоднородностью. В некоторых районах области количество детей с виражом туберкулиновых реакций остается высоким или продолжает увеличиваться. Такие тенденции могут быть связаны с уровнем заболеваемости туберкулёзом и наличием больных с открытыми формами туберкулёза органов дыхания в этих районах.</p></sec><sec><title>Заключение</title><p>Заключение. Для повышения эффективности профилактики развития активного туберкулёза у детей России в 2010 г. в Тюменской области на основе изучения иммунологических показателей в группах детей с высокой чувствительностью и гиперреакцией на пробы Манту с 2ТЕ разработана математическая модель иммунного ответа, которая с успехом может быть использована для диагностики и оценки особенностей течения туберкулёзной инфекции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Tuberculosis in Russia is one of the primary problems of epidemiology and public health.</p></sec><sec><title>The purpose</title><p>The purpose: to analyze the epidemic situation of tuberculosis in high-risk groups of children and adolescents in the Tyumen region of Russia.</p></sec><sec><title>Material and methods</title><p>Material and methods. Were analyzed the annual reporting forms No. 33 «Information about patients with tuberculosis» for 2014-2018 in the Tyumen region.</p></sec><sec><title>Results</title><p>Results. According to our research, research materials in the region, WHO recommendations for eliminating tuberculosis by 2035 the need to develop new approaches and practical recommendations for clinical dispensary observation of children with altered tuberculin sensitivity is justified.</p></sec><sec><title>Discussion</title><p>Discussion. The epidemic situation among children with altered tuberculin sensitivity by 2018 in the districts of the Tyumen region is characterizing by its heterogeneity. In some districts of the region, the number of children with a turn of tuberculin reactions remains high or continues to increase. Such trends can be associated with the incidence of tuberculosis and the presence of patients with open forms of respiratory tuberculosis in these areas.</p></sec><sec><title>Conclusion</title><p>Conclusion. To improve the efficiency of preventing the development of active tuberculosis in Russian children in 2010, a mathematical model of immune response developed in the Tyumen Region based on the study of immunological indices in groups of children with high sensitivity and hyperresponsiveness to the Mantoux tests 2TE samples. The model can be successfully used for diagnostics and assess the characteristics of the course of tuberculosis infection.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>фтизиатрия</kwd><kwd>дети</kwd><kwd>подростки</kwd><kwd>группа риска</kwd><kwd>профилактика</kwd><kwd>диспансерное наблюдение</kwd><kwd>измененная туберкулиновая чувствительность</kwd><kwd>стратегия ВОЗ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>phthisiology</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>risk group</kwd><kwd>prevention</kwd><kwd>follow-up</kwd><kwd>altered tuberculin sensitivity</kwd><kwd>WHO strategy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аксенова В.А., Севостьянова Т.А. Туберкулёз у детей и подростков в России. Лечащий врач. 2013; (1): 35-9.</mixed-citation><mixed-citation xml:lang="en">Aksenova V.A., Sevost’yanova T.A. 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