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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rfhealth</journal-id><journal-title-group><journal-title xml:lang="ru">Здравоохранение Российской Федерации</journal-title><trans-title-group xml:lang="en"><trans-title>Health care of the Russian Federation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0044-197X</issn><issn pub-type="epub">2412-0723</issn><publisher><publisher-name>Federal Scientific Center of Hygiene named after F.F. Erisman</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47470/0044-197X-2023-67-6-510-518</article-id><article-id custom-type="edn" pub-id-type="custom">zdaujj</article-id><article-id custom-type="elpub" pub-id-type="custom">rfhealth-1428</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИКА ИНФЕКЦИОННЫХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTION OF INFECTIOUS DISEASES</subject></subj-group></article-categories><title-group><article-title>Вариативность параметров эпидемического процесса COVID-19, обусловленная влиянием региональных социально-гигиенических факторов</article-title><trans-title-group xml:lang="en"><trans-title>Variability of parameters of the COVID-19 epidemic process due to influence of regional social-hygienic factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2356-1145</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцева</surname><given-names>Нина В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaitseva</surname><given-names>Nina V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2534-5713</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клейн</surname><given-names>Светлана В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kleyn</surname><given-names>Svetlana V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5850-7232</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеев</surname><given-names>Вадим Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseev</surname><given-names>Vadim B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5406-4961</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирьянов</surname><given-names>Дмитрий А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiryanov</surname><given-names>Dmitry A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4755-8306</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глухих</surname><given-names>Максим Владиславович</given-names></name><name name-style="western" xml:lang="en"><surname>Glukhikh</surname><given-names>Maxim V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мл. науч. сотр. отдела системных методов санитарно-гигиенического анализа и мониторинга ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Роспотребнадзора, 614045, Пермь.</p><p>e-mail: gluhih@fcrisk.ru</p></bio><bio xml:lang="en"><p>Junior research fellow at the Department of sanitary and hygienic analysis and monitoring systemic methods, Perm, 614045, Russian Federation.</p><p>e-mail: gluhih@crisk.ru</p></bio><email xlink:type="simple">gluhih@fcrisk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Scientific Center for Medical and Preventive Health Risk Management Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2023</year></pub-date><volume>67</volume><issue>6</issue><fpage>510</fpage><lpage>518</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зайцева Н.В., Клейн С.В., Алексеев В.Б., Кирьянов Д.А., Глухих М.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Зайцева Н.В., Клейн С.В., Алексеев В.Б., Кирьянов Д.А., Глухих М.В.</copyright-holder><copyright-holder xml:lang="en">Zaitseva N.V., Kleyn S.V., Alekseev V.B., Kiryanov D.A., Glukhikh M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rfhealth.ru/jour/article/view/1428">https://www.rfhealth.ru/jour/article/view/1428</self-uri><abstract><sec><title>Введение</title><p>Введение. В рамках теории о саморегуляции паразитарных систем природно-социальные факторы рассматриваются не только как необходимое условие взаимодействия популяций возбудителя инфекционного заболевания и восприимчивых организмов, но и как регуляторы фазовых преобразований эпидемического процесса. Эпидемический процесс COVID-19, соответствуя положениям данной теории, должен обусловливаться влиянием определённой комбинации факторов среды обитания.</p><p>Цель исследования — установить приоритетные социально-гигиенические факторы среды обитания, модифицирующие течение эпидемического процесса COVID-19 на территории России.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Для установления причинно-следственных связей между факторами среды обитания и параметрами эпидемического процесса COVID-19 использованы корреляционно-регрессионный и факторный анализы. В качестве зависимых переменных выступали параметры эпидемического процесса COVID-19 на основе компартментной модели SIR+L. Общее количество исследуемых факторов составило 263 единицы, условно разделённых на 7 групп (противоэпидемические мероприятия, факторы среды обитания и др.).</p></sec><sec><title>Результаты</title><p>Результаты. В результате исследования установлено, что одними из наиболее приоритетных статистически значимых факторов являются показатели противоэпидемических мероприятий («охват вакцинацией населения» особенно в старших возрастах; r = –0,67–(–)0,69), показатели экономической развитости территорий (валовый региональный продукт; r = –0,22), показатели экономического благополучия населения (расходы домохозяйств на покупку продуктов питания; r = 0,27), показатели образа жизни населения (продажи алкогольной продукции по видам; r = 0,21–0,38), показатели качества среды обитания, в том числе рабочей среды (r = 0,11–0,22), показатели урбанизации территорий (плотность автомобильных дорог; r = 0,18), погодно-климатические показатели (среднемесячная температура воздуха; r = 0,22, среднемесячная инсоляция; r = –0,25) и др.</p><p>Ограничения исследования — набор исследуемых факторов и период их анализа.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные оценки влияния факторов среды обитания на условия течения эпидемического процесса COVID-19 могут быть использованы при разработке системных стратегических решений по сохранению здоровья населения, повышению уровня его безопасности в масштабе регионов и страны.</p><p>Соблюдение этических стандартов. Для проведения данного исследования не требовалось заключения комитета по биомедицинской этике (исследование выполнено на общедоступных данных официальной статистики).</p></sec><sec><title>Участие авторов</title><p>Участие авторов:Зайцева Н.В. — концепция и дизайн исследования, редактирование, утверждение окончательного варианта статьи;Клейн С.В. — редактирование, написание текста, утверждение окончательного варианта статьи;Алексеев В.Б. — концепция и дизайн исследования, редактирование, утверждение окончательного варианта статьи;Кирьянов Д.А. — редактирование, написание текста, утверждение окончательного варианта статьи;Глухих М.В. — сбор и обработка материала, статистическая обработка данных, написание текста.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.</p></sec><sec><title>Финансирование</title><p>Финансирование. Исследование не имело спонсорской поддержки.</p></sec><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p></sec><sec><title>Поступила 13</title><p>Поступила 13.08.2023Принята в печать 11.10.2023Опубликована 23.12.2023</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Within the theory on self-regulation of parasitic systems, natural and social factors are considered not only the necessary condition for interaction between an infectious agent and susceptible organisms but they are also seen as regulators of phase transformations over the epidemic process. The COVID-19 epidemic process, if it conforms to postulates outlined in this theory, should be determined by influence of certain combination of environmental factors.</p></sec><sec><title>The purpose of the study</title><p>The purpose of the study. To establish priority social and hygienic environmental factors potent of modifying COVID-19 epidemic process on the RF territory.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. We applied correlation-regression and factor analysis to establish cause-effect relations between environmental factors and parameters of the COVID-19 epidemic process. Parameters of the COVID-19 epidemic process were identified based on the SIR+L compartment model and used as dependent variables. Overall, 263 factors were examined; they were conditionally divided into seven groups (anti-epidemic activities, environment, etc.).</p></sec><sec><title>Results</title><p>Results. The study findings revealed several priority statistically significant factors. They include anti-epidemic activities (“population covered by vaccination” especially in older age groups (r = –0.67–(–)0.69)), levels of economic development on a given territory (gross regional product (r = –0.22)), socioeconomic wellbeing of population (households’ expenditures on food (r = 0.27)), lifestyle indicators (retail alcohol sales as per specific products (r = 0.21–0.38)), quality of the environment, workplace included (r = 0.11–0.22), urbanization (motorway density (r = 0.18)), weather and climatic factors (average monthly temperatures (r = 0.22), average monthly insolation (r = –0.25)) and others.</p></sec><sec><title>Limitations</title><p>Limitations. The set of the examined priority factors and a period of their analysis can be considered limitations of the present study.</p></sec><sec><title>Conclusion</title><p>Conclusion. The obtained estimates as regards the priority environmental factors determining the COVID-19 epidemic process can be used when developing systemic strategic decisions on public health protection and securing its safety both in specific regions and the country as a whole.</p><p>Compliance with ethical standards. The study does not require the approval of a biomedical ethics committee of other documents (the study was performed using publicly available official statistics).</p><p>Contribution of the authors:Zaitseva N.V. — research concept and design, editing, approval of the final version of the article;Kleyn S.V. — editing, writing the text, approval of the final version of the article;Alekseev V.B. — research concept and design, editing, approval of the final version of the article;Kiryanov D.A. — editing, writing the text, approval of the final version of the article;Glukhikh M.V. — statistical data processing, collection and processing material, writing the text.All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.</p></sec><sec><title>Acknowledgment</title><p>Acknowledgment. The study had no sponsorship.</p></sec><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>Received</title><p>Received: August 13, 2023Accepted: October 11, 2023Published: December 23, 2023</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>эпидемический процесс</kwd><kwd>параметры SIR(+L) модели</kwd><kwd>корреляционно-регрессионный анализ</kwd><kwd>приоритетные факторы</kwd><kwd>социально-гигиенические факторы</kwd><kwd>среда обитания</kwd><kwd>образ жизни</kwd><kwd>противоэпидемические мероприятия</kwd><kwd>экономические факторы</kwd><kwd>погодно-климатические факторы</kwd><kwd>социально-демографические факторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>epidemic process</kwd><kwd>SIR(+L) model parameters</kwd><kwd>correlation and regression analysis</kwd><kwd>priority factors</kwd><kwd>socio-hygienic factors</kwd><kwd>environment</kwd><kwd>lifestyle</kwd><kwd>anti-epidemic activities</kwd><kwd>economic factors</kwd><kwd>weather and climatic factors</kwd><kwd>sociodemographic factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">McArthur D.B. 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